Synthesis of 4-Hydroxy-2 (1H)-quinolone Derivatives
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چکیده
منابع مشابه
A Facile Synthesis of 4-Hydroxycoumarin and 4-Hydroxy-2-quinolone Derivatives
Coumarin derivatives possessing diverse biological activities play important roles as versatile building blocks for the synthesis of natural products and biologically active compounds. In particular, 4-hydroxycoumarin derivatives, such as 4-hydroxycoumarin and 4-hydroxythiocoumarin, have been used as useful intermediates for the synthesis of anticoagulants, herbicides, and anticancer agents. Re...
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Background: An efficient, promoted tri-component catalytic reaction between barbituric acid (or N,N-dimethyl barbituric acid), 4-hydroxy coumarin, and a wide range of aryl aldehydes using zinc oxide nanowires (ZnO NWs) to obtain some new 4-hydroxychromenylarylmethyl-6-hydroxypyrimidine-2,4-diones is described. Method: The reactants were successfully condensed ...
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1-Hydroxy-2-dodecyl-4(1H)quinolone (HDQ) was recently identified as a Toxoplasma gondii inhibitor. We describe here two novel 1-hydroxyquinolones, which displayed 50% inhibitory concentrations 10- and 5-fold lower than that of HDQ. In a mouse model of acute toxoplasmosis, these two compounds and HDQ reduced the percentages of infected peritoneal cells and decreased the parasite loads in lungs a...
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Background: Selective phosphodiesterase (PDE3) inhibitors improve cardiac contractility and may use in congestive heart failure. However, their proarrhythmic potential is the most important side effect. Methods: In this research, we evaluated the potential cardiotonic activity of six new synthesized selective PDE3 inhibitors (6-hydroxy-4-methylquinolin-2(1H)-one derivatives) using the spontan...
متن کاملSynthesis of Some7 -Methoxy-2-(lH)-quinolone Derivatives
Reaction of 4-hydroxy-7-methoxy-2(lH)-quinolone (1) with iodosobenzenes, prepared in situ from the dichloroiodo compounds 2a,b, afforded the iodoniumylides 3a,b in good yields. Their thermal rearrangement produced the 3-iodo-4-aryloxy-quinolones 4a,b. Reductive -deiodinatton of 4a,b gave the corresponding arylethers 5a,b. By photocyclization 4a as well as 5a yielded the benzofuro-quinolone 6a (...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1970
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.90.7_818